International Journal of Pharmaceutical Research and Nanotechnology

Authors: Garima Jain, Nitin Kaushik

Abstract: Rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) are chronic autoimmune diseases that significantly affect patients' quality of life. Traditional treatments often involve broad-spectrum immunosuppressants with potential adverse effects and limited efficacy. Recent advancements in understanding the molecular and immunological pathways underlying these diseases have led to the development of novel therapeutic strategies. This paper reviews new treatments, including biologics, small molecule inhibitors, and emerging therapies, highlighting their mechanisms of action, efficacy, and safety profiles. The discussion also covers the potential of personalized medicine in optimizing treatment outcomes for RA and SLE patients.

Keywords: Rheumatoid arthritis, Systemic lupus erythematosus, Biologics, Small molecule inhibitors, Janus kinase inhibitors, Tumor necrosis factor inhibitors, B-cell depletion therapy, BAFF inhibitors, Personalized medicine, Autoimmune diseases