Journal of Research in Applied Chemistry

Authors: V.Mala, S. P. Sakthinathan, G. Vanangamudi, G. Thirunarayanan

Abstract: A series of novel chalcones have been synthesized by SiO2-H2SO4 catalyzed microwave assisted oxidative coupling of ketones and aldehydes under solventfree conditions. The yield of the chalcones has been found to be more than 90%. The purity of all chalcones has been checked using their physical constants and spectral data as published earlier in literature. The spectral frequencies of these chalcones have been correlated withHammett substituent constants, F and R parameters. From the results of statistical analyses the effects of substituent on the group frequencies were discussed.The antimicrobial activities these chalcones have been studied using Bauer-Kirby method.