Perspectives of Glucose-6-Phosphate Deficiency-Overview

Abstract

Glucose-6-phosphate dehydrogenase (G6PD) deficiency which is a genetic disorder, it is an X-linked hereditary defect caused by the mutations in the G6PD gene. G6PD deficiency is one of the most prevalent human enzymopathies affecting more than 400 million individuals worldwide, and particularly in those undeveloped and the resource-limited countries. The clinical phenotype of G6PD deficiency varies significantly from the asymptomatic to neonatal jaundice, kernicterus, or the acute hemolytic anemia following the ingestion of certain drugs during some infections, and notably through eating the fava beans (favism).

KEYWORDS: Glucose-6-phosphate dehydrogenase (G6PD), deficiency, enzymopathies, hemolytic anemia, X-linked hereditary, fava beans (favism).