The Transactions on Scalable Data Science Infrastructure, published by Mantech Publications, is a peer-reviewed international journal dedicated to advancing research in large-scale data-driven systems and next-generation analytical infrastructures. The journal focuses on scalable architectures for big data processing, distributed data platforms, cloud-based analytics, high-performance computing, and intelligent data pipelines. It provides a scholarly forum for researchers, data scientists, and industry practitioners to present innovative solutions that address the challenges of volume, velocity, and variety in modern data ecosystems. Emphasizing originality, technical depth, and real-world relevance, the journal features high-quality research articles, systematic reviews, and experimental studies. Through interdisciplinary collaboration and rigorous peer review, it aims to strengthen the foundation of scalable, secure, and intelligent data science infrastructures that power emerging digital technologies.