Prakriti Based Variations in Musculoskeletal Architecture and Physiological Performance—an Ayurvedic Exploratory Analysis

Abstract

Abstract

Prakriti, the constitution determined at conception by the tri dosha balance, is posited to influence morphology and function across the lifespan. In this cross sectional study involving 180 healthy adults stratified into Vataja, Pittaja, and Kaphaja prakriti groups via validated phenotype questionnaires and genomic markers (CYP2C19, PON1 haplotypes), dual energy X ray absorptiometry and ultrasound shear wave elastography quantify musculoskeletal attributes. Performance metrics—maximum voluntary contraction, VO?max, and gait kinetics—are recorded alongside serum metabolite panels. Results reveal significantly greater cortical thickness and force generation in Kaphaja individuals, elevated mitochondrial respiration efficiency in Pittaja, and superior joint mobility but lower bone density in Vataja types. Metabolomic signatures display prakriti specific clusters, suggesting underlying biochemical substrates for phenotypic diversity.

Keywords:Prakriti, Dosha, Bone density, VO?max, Metabolomics