Journal of Research in Microbiology and Immunology ISSN: 3108-0952 (Online)

Authors: Dhiraj Malhotra, Payal Gupta

Abstract: This study focuses on unraveling the molecular mechanisms underlying antibiotic resistance in Staphylococcus aureus, a significant causative agent of both hospital- and community-acquired infections. Given the alarming rise in antibiotic-resistant strains of S. aureus, including MRSA (Methicillin Resistant Staphylococcus aureus), understanding these mechanisms are crucial for developing effective treatment strategies. We employed a combination of microbiological and molecular biology techniques to examine the resistance patterns and underlying genetic and biochemical factors in various S. aureus strains. Our methods included antibiotic susceptibility testing, PCR amplification, and sequencing of key resistance genes. The study revealed diverse resistance profiles and identified specific genetic mutations associated with resistance to several commonly used antibiotics. These findings provide insights into the adaptive strategies of S. aureus and highlight potential targets for novel therapeutic interventions. The study underscores the need for continued research into bacterial resistance mechanisms to inform the development of effective and sustainable treatment strategies against S. aureus infections.

Keywords: - Staphylococcus aureus, Antibiotic Resistance, Molecular Mechanisms, Treatment Strategies, Bacterial Pathogenesis