Journal of Research in Microbiology and Immunology ISSN: 3108-0952 (Online)

Authors: Dr. Meera Kapoor, Dr. Arjun Nair

Abstract: Inflammatory diseases, including inflammatory bowel disease, rheumatoid arthritis, and metabolic disorders, are characterized by dysregulated immune responses. Probiotics with immunomodulatory properties offer promising therapeutic avenues by restoring microbial balance and modulating host immune pathways. This paper examines the development of immunomodulatory probiotics, focusing on molecular mechanisms by which probiotics influence innate and adaptive immunity, cytokine production, and gut barrier integrity. Tables summarizing probiotic strains, their immune- modulatory effects, and targeted inflammatory diseases are provided. Advances in genetic engineering, prebiotic co-administration, and strain selection strategies are discussed. Understanding probiotic-host immune interactions can inform the development of safe and effective probiotic therapeutics to manage inflammatory diseases.

Keywords:Immunomodulatory probiotics, Inflammatory diseases, Cytokine modulation, Gut microbiota, Adaptive immunity, Therapeutic probiotics, Immune homeostasis