Authors : Dr. Priya Nair, Arjun Deshmukh
Abstract: Quorum sensing (QS) is a microbial communication mechanism that regulates collective behavior, including virulence factor expression, biofilm formation, and antibiotic resistance. This paper reviews the molecular mechanisms of QS in bacteria and fungi, highlighting its role in pathogenicity and host interaction. Key QS systems, signaling molecules, and their effect on virulence gene regulation are discussed. A table summarizing major pathogens, their QS signals, and associated virulence traits is provided. Understanding QS-mediated virulence modulation offers potential for novel therapeutic interventions targeting microbial communication to control infections and reduce antimicrobial resistance.
Keywords: Quorum sensing, virulence regulation, autoinducers, biofilm formation, bacterial communication, pathogenicity, antimicrobial resistance, signaling molecules
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