Author: Karanjkar Mayuri Bandu
Abstarct: Chromatography is the important technique of separation science and used in all pharmaceutical industries and research laboratories. High Performance Liquid Chromatography is the most important technique used to identify, detect, separate and quantify the drug. There are various chromatographic parameters were analyzed like physiochemical properties of drug, chromatographic conditions, sample preparation, detection of analyte etc. Review the method development and validation of HPLC system is the main objective of these articles. Validation of HPLC method contains system suitability, specificity, linearity, range, accuracy, precision, robustness, LOD, LOQ. Validation of HPLC system is done as per ICH guidelines.
Keywords: Chromatography, HPLC, Validation, ICH guidelines.
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