Journal of Pathology, Communicable Diseases and Preventive Medicines

Authors:-Alok Tiwari,  Prashant Mathur

Abstract:-This research paper provides an in-depth analysis of the pathogenic mechanisms of the Zika virus (ZIKV) and its implications for vaccine and therapeutic development. Zika virus, a mosquito-borne flavivirus, has emerged as a significant global health concern due to its rapid spread and association with neurological disorders such as microcephaly in infants and Guillain-Barré syndrome in adults. This study aimed to elucidate the molecular and cellular mechanisms underlying Zika virus pathogenesis. We employed a combination of virological, molecular biology, and immunological techniques, including the use of various viral strains and cell lines, RNA sequencing, and protein assays. Our findings offer novel insights into the virus-host interactions, particularly how ZIKV evades immune responses and induces pathogenesis. These insights are pivotal for informing the development of effective vaccines and antiviral therapies. The study significantly contributes to the understanding of ZIKV biology and lays the groundwork for future research in combating this global health threat.

Keywords:-Zika Virus, Pathogenesis, Vaccine Development, Antiviral Therapies, Viral Mechanisms