Journal of Pathology, Communicable Diseases and Preventive Medicines

Authors: Arjun Dahal, G. Sivakumar, S. Ramesh Babu

Abstract: Over the last several years, scientific study has focused on the possible significance of hyperuricemia as a cardiovascular risk factor; the major focus has been on persistently elevated plasma uric acid levels. Although some studies have not found a strong link between hyperuricemia and cardiovascular risk, the majority of scientific evidence agrees that hyperuricemia is important in determining cardiovascular events and the development of other risk factors, which are frequently associated with only moderately elevated serum uric acid levels. The pathophysiological mechanisms behind this connection include mostly hyperuricemia-induced endothelial dysfunction, as well as inflammatory and oxidative stress caused by high blood uric acid levels. Early detection, follow-up, and preventative measures, as well as successful hyperuricemia therapy, are especially suggested in patients with additional concurrent cardiovascular risk factors. Urate-lowering medication should aim to achieve a serum uric acid level of less than 6 mg/dL (360 mol/L), while in high-risk individuals, the lowest feasible value of uric acid is preferable.

Keywords: Cardiovascular Disease, Worldwide Risk, pathophysiological Mechanisms, Hyperuricemia Therapy