Journal of Pathology, Communicable Diseases and Preventive Medicines

Authors: Priyam Jain, Yogesh Kirar, Sameer Thakur

Abstract: In Parkinson's disease, dopaminergic neurons in the substantia nigra region of the brain gradually degenerate, resulting in a progressive loss of function. Because the origin of this disease is unclear, treatment is symptomatic and ineffective in terms of slowing the progression of the condition. Recent research, on the other hand, has established a clear link between neuroinflammation and proinflammatory cytokines and the pathophysiology of several diseases. A discussion of the relationship between proinflammatory cytokines and the pathophysiology of Parkinson's disease is presented in this paper, which also considers current therapy options that target these pathways.

Keywords: Parkinson's disease; Neurodegenerative disease; Neuroinflammation; Current approaches; Proinflammatory cytokines