Journal of Pathology, Communicable Diseases and Preventive Medicines

Authors: Yuvrajsinh Solanki, Preetu Shukla, Dr. U. M. Upadhyay

Abstract: Cirrhosis is defined as the histological development of regenerative nodules surrounded by fibrous bands in response to chronic liver injury, which leads to portal hypertension and end stage liver diseases. Recent advances in the understanding of the natural history and pathophysiology of cirrhosis, and in treatment of its complications, have resulted in improved management, quality of life and life expectancy of patients. Liver transplantation remains the only curative options for selected group of patients, but pharmacological treatments that can halt progression to decomposed cirrhosis or even reverse cirrhosis are currently being developed. This review focuses on the history, causes, sign & symptoms, diagnosis, complications, and management of cirrhosis and new clinical and scientific developments.

Keywords: Liver Cirrhosis, Pathogenesis, Cytokine, Fibrosis, Etiology, HVPG, Endoscopy.