Journal of Pharmaceutical Chemistry and Drug formulation ISSN: 3108-0782 (Online)

Authors: Dr. Neha Sharma, Dr. Arjun Patel

Abstract: Sustained release (SR) implants are advanced drug delivery systems designed to provide continuous therapeutic levels over extended periods. These implants improve patient compliance, reduce dosing frequency, and maintain stable plasma drug concentrations. This paper explores the design principles, materials, preparation methods, and clinical applications of SR implants. Biodegradable and non-biodegradable polymers are discussed with respect to drug release kinetics, biocompatibility, and safety. Analytical and characterization techniques such as scanning electron microscopy, in vitro release studies, and mechanical testing are highlighted. Case studies of hormone therapy, antipsychotic medications, and oncology implants illustrate the clinical relevance. Regulatory guidelines, challenges in formulation, and future trends in personalized and smart implants are also addressed.

Keywords: Sustained release implants, Biodegradable polymers, Non-biodegradable polymers, Drug delivery, Controlled release, Clinical applications, Biocompatibility.