Authors: Pooja Srivastava1, Alka Goyal2
Abstract: In silico strategies for rational drug design include quantitative structure activity relationship (QSAR) and quantitative structure-property relationship (QSPR) research. The goal of these strategies is to enhance the biological activity and physicochemical qualities of current leads. Predicting the biological actions of unproven and often yet unavailable substances is another goal. This article offers a broad review of many QSAR/QSPR investigations from past research. In certain research, the R2 and Q2 parameters are utilised to predict the predictability and resilience of the created models. QSAR studies were used in all of the papers listed to investigate pharmacological activity or binding mode on individual receptors.
Keywords: Squared Correlation Coefficient Q2, physicochemical qualities, Molecular Descriptor, Drug design
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