Journal of Pharmaceutical Chemistry and Drug formulation ISSN: 3108-0782 (Online)

Authors: Ananya Gupta, Dr. Rahul Mehta

Abstract: Transdermal drug delivery systems (TDDS) offer controlled and sustained release of drugs, improving bioavailability, patient compliance, and minimizing first-pass metabolism. This study focuses on the formulation and evaluation of TDDS using polymeric matrices, permeation enhancers, and plasticizers to optimize drug release kinetics. Various in vitro evaluation techniques, including drug content uniformity, moisture uptake, tensile strength, and in vitro diffusion studies, were employed. The influence of polymer composition, drug load, and matrix thickness on release profiles was systematically assessed. A representative table summarizes the effect of formulation variables on key parameters such as drug release, tensile strength, and moisture content. Results indicate that optimized TDDS provide sustained drug release over 24–72 hours, maintain mechanical integrity, and ensure consistent drug delivery. The study demonstrates the potential of TDDS as a versatile platform for controlled release therapy and underscores the importance of systematic formulation and evaluation in developing efficient transdermal systems.

Keywords: Transdermal drug delivery, controlled release, polymeric matrix, permeation enhancers, in vitro diffusion, drug content uniformity, formulation optimization