Journal of Pharmaceutical Chemistry and Drug formulation ISSN: 3108-0782 (Online)

Authors:Dnyaneshwar S. Jagtap, Gajanan Gavande, Dr. Savita Sonawane, Dr. Vishal Babar 

Abstract: A series of equations are developed to study the effects of cosolvents on a solution's solubility in mixed solutions where a finite solubility is shown in the solution. The equations differ according to the scale used for the concentrations of the solute (and cosolvent). In the formulation of liquid pharmaceutical formulations, a poorly water-soluble drug's solubilization has an important role. There are a variety of approaches used to affect solubility. A water-miscible cosolvent called co-solvency which is one of the most efficient and readily available methods. A simplified view of cosolvent selection includes the analysis of observable properties of various cosolvent systems and the application of empirical evidence. Solubility is a chemical property referring to a given substance's ability, the solute, to dissolve in a solvent. It is measured in terms of the maximum amount of solute dissolved in a solvent at equilibrium. The resulting solution is called a saturated solution, and cosolvent is responsible for it. Cosolvents have some degree of hydrogen bond donating and or hydrogen bond accepting ability and small hydrocarbon regions. The resulting solution will have physical properties that are intermediate to that of the pure organic solvent and water through the reduction of water–water interaction.

Keywords: Solubility, solubility enhancement, and co-solvency.