Authors:-Ms. Reena Thakur, Rupali, Shivali Singla, Sachin Goyal
Abstract:-Terbutaline sulfate fast dissolving sublingual films were prepared using drug compatible film formers in different combinations and proportions. The film polymers are maltodextrin, HPMC E15, PVP K-25. Propylene glycol and sorbitol were used as plasticizers and mannitol as filler. The optimum polymer concentrations and the plasticizer amount were selected on the basis of flexibility, tensile strength, and stickiness of the films. The prepared films were evaluated for their tensile strength, thickness uniformity, disintegration time (in vitro), in vitro dissolution, and moisture content. Polymer type rather than total polymer concentration or plasticizer amount showed a significant effect on the tested film properties Sublingual films could be promising as a convenient delivery system for terbutaline sulfate in patientswith swallowing problems. Among all, the formulation F9 showed release up to 97.8% of the drug in 10 min.
Full Issue
| View or download the full issue | PDF 118-131 |