Journal of Pharmaceutical Chemistry and Drug formulation ISSN: 3108-0782 (Online)

Authors: Dr. Rohan Mehta, Dr. Sneha Verma

Abstract: Microparticles and nanoparticles have revolutionized drug formulation by improving solubility, stability, bioavailability, and targeted delivery of therapeutic agents. This paper explores the principles, types, preparation methods, and applications of micro- and nanocarriers in pharmaceutical formulations. Emphasis is placed on polymeric, lipid-based, and inorganic carriers, along with strategies for controlling drug release kinetics. Analytical techniques for characterization, such as dynamic light scattering (DLS), electron microscopy, and spectroscopy, are discussed. Case studies demonstrate the clinical relevance of particle-based formulations in cancer therapy, vaccines, and chronic disease management. Regulatory considerations and future perspectives, including smart nanoparticles and personalized medicine, are highlighted to illustrate the growing significance of microparticles and nanoparticles in modern drug delivery.

Keywords: Microparticles, Nanoparticles, Drug delivery, Bioavailability, Controlled release, Targeted therapy, Polymer carriers, Lipid carriers.