Authors: Dr. Anjali Mehta, Dr. Karthik Rao
Abstract: Poor aqueous solubility is a major challenge in drug development, often limiting bioavailability and therapeutic efficacy. Pharmaceutical co-crystals, defined as multi-component crystalline systems composed of an active pharmaceutical ingredient (API) and a co-former, offer a promising approach to enhance solubility without altering the pharmacological activity of the drug. This paper reviews the role of co-crystals in improving drug solubility and dissolution rates, highlighting preparation methods, characterization techniques, and formulation strategies. Comparative analysis of co-crystals versus traditional solubility enhancement methods is presented. Regulatory considerations, case studies, and future perspectives in the application of co-crystals for bioavailability enhancement are also discussed, emphasizing their potential in modern drug formulation.
Keywords: Co-crystals, Solubility enhancement, Bioavailability, Active pharmaceutical ingredient (API), Dissolution, Solid-state engineering, Pharmaceutical formulation.
Full Issue
| View or download the full issue | PDF 95-99 |