Author: Preeti Reddy
Abstract: Poor solubility is a significant challenge in drug formulation, often limiting the bioavailability and therapeutic efficacy of medications. This paper explores various formulation strategies employed to enhance the bioavailability of poorly soluble drugs. We discuss approaches such as solid dispersion, lipid-based formulations, micronization, and the use of cyclodextrins and surfactants. Each method's principles, advantages, and limitations are analyzed, providing a comprehensive understanding of their applications in pharmaceutical chemistry. By improving the solubility and, consequently, the bioavailability of drugs, these formulation strategies enable the development of more effective treatments for a wide range of medical conditions.
Keywords: Bioavailability, Poor Solubility, Solid Dispersion, Lipid-Based Formulations, Micronization
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