Authors: Dr. Radhika Jain, Dr. Saurabh Verma
Abstract: Polymorphism, the occurrence of different crystalline forms of a drug, plays a critical role in pharmaceutical development. Variations in crystal structure can significantly affect solubility, dissolution rate, stability, and ultimately the bioavailability of drugs. This paper explores the phenomenon of polymorphism, methods for its detection and characterization, and its impact on drug formulation and therapeutic efficacy. Various case studies highlight challenges and solutions in optimizing polymorphic forms for maximum bioavailability. Additionally, the paper discusses regulatory considerations, formulation strategies, and future perspectives for managing polymorphism in drug development to ensure consistent efficacy and safety.
Keywords: Polymorphism, Bioavailability, Solubility, Dissolution rate, Crystal forms, Drug stability, Pharmaceutical formulation.
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