Authors: Dr. Meera Sharma, Dr. Ankit Singh
Abstract: Lipid-based drug delivery systems (LBDDS) have emerged as an effective strategy to improve the solubility, bioavailability, and therapeutic efficacy of poorly water-soluble drugs. These systems, including liposomes, solid lipid nanoparticles (SLNs), and self-emulsifying drug delivery systems (SEDDS), utilize lipid carriers to enhance drug solubilization and absorption. This paper reviews formulation strategies, stability considerations, and characterization techniques for LBDDS. Factors affecting physical and chemical stability, such as lipid type, surfactants, storage conditions, and particle size, are discussed. Comparative analysis of different LBDDS types, case studies, and future perspectives provide insights into optimizing therapeutic performance. The integration of nanotechnology and advanced lipid carriers holds promise for developing effective and stable drug delivery systems.
Keywords: Lipid-based drug delivery systems, Liposomes, Solid lipid nanoparticles, SEDDS, Drug solubility, Bioavailability, Stability, Formulation.
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