Journal of Pharmaceutical Chemistry and Drug formulation ISSN: 3108-0782 (Online)

Authors: Dr. Satendra Singh, Gaurav Malhotra

Abstract: Oral drug delivery is the most convenient and preferred route for administering medications due to its ease of administration, patient compliance, and cost-effectiveness. However, the gastrointestinal (GI) tract presents numerous physiological barriers that can limit drug absorption and bioavailability. This paper aims to provide an overview of the challenges associated with oral drug delivery and discusses various strategies and technologies employed to enhance drug absorption and overcome the barriers in the GI tract.

Keywords: Oral drug delivery, gastrointestinal barriers, drug absorption, bioavailability, formulation approaches, permeation enhancers, nanotechnology, mucoadhesive systems, targeted drug delivery, regulatory considerations