Vol 5, No 1 (2023)

Innovative Approaches for Solubility Enhancement of Poorly Water-Soluble Drugs

Authors: Mridul Gupta, Pooja Singh

Abstract: Poor solubility is a significant challenge in pharmaceutical development, as it can greatly hinder drug absorption, bioavailability, and therapeutic efficacy. Enhancing the solubility of poorly water-soluble drugs has thus become a critical area of research in the pharmaceutical industry. This paper explores innovative approaches that have been employed to overcome solubility limitations, including physicochemical modifications, formulation techniques, and novel drug delivery systems. By enhancing drug solubility, these approaches offer promising solutions for improving drug delivery, patient compliance, and overall therapeutic outcomes.

Keywords: Solubility enhancement, Poorly water-soluble drugs, Physicochemical modifications, Formulation techniques, Novel drug delivery systems, Combination Characterization techniques

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