Journal of Pharmaceutical Chemistry and Drug formulation ISSN: 3108-0782 (Online)

Authors: Dr. Anjali Kapoor, Dr. Vikram Singh

ABSTRACT: Orally disintegrating tablets (ODTs) provide a patient-friendly dosage form, particularly suitable for pediatric populations who often face difficulty in swallowing conventional tablets. This paper explores formulation strategies for ODTs, including selection of superdisintegrants, taste-masking agents, and excipients to optimize disintegration time and stability. Preparation methods such as direct compression, lyophilization, and molding are discussed. The impact of excipient-drug interactions on mechanical strength, dissolution, and bioavailability is examined. Tables summarizing common excipients, their functions, and effects on pediatric ODT performance are included. Regulatory considerations and analytical approaches for quality assessment are presented. This review highlights the critical factors in developing safe, effective, and palatable ODTs for children.

Keywords: Orally disintegrating tablets, Pediatric formulations, Superdisintegrants, Taste masking, Direct compression, Lyophilization, Drug stability.