Authors: Dr. Priya Nair, Dr. Rohit Verma
ABSTRACT: Buccal and sublingual drug delivery systems (BDDS and SDDS) provide non invasive routes for rapid drug absorption and improved bioavailability, bypassing the first-pass metabolism associated with oral administration. These systems are particularly useful for drugs requiring rapid onset of action or those with poor gastrointestinal stability. This paper reviews the formulation strategies, excipient selection, and design considerations for buccal and sublingual drug delivery. Factors affecting mucoadhesion, drug release, and permeation are discussed. Comparative analysis of various dosage forms, including films, tablets, and lozenges, is presented. Stability, patient compliance, and clinical applications are evaluated, emphasizing the role of BDDS and SDDS in enhancing therapeutic outcomes and enabling patient-centric medication.
Keywords: Buccal drug delivery, Sublingual drug delivery, Mucoadhesive systems, Rapid absorption, Bioavailability, Films, Tablets, Mucosal permeation.
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