Author: Rasika Chimurkar, Sampurna Gharat, Jeeja Pananchery, Dr. Ashish Jain
Abstract: Microemulsions, which are optically isotropic and thermodynamically stable systems of water, oil, surfactant, and/or co-surfactant, have been studied as drug delivery systems because of their capacity to solubilize poorly water soluble drugs as well as their enhancement of topical and systemic availability. It helps to solubilize the lipophilic drug moiety and it shows rapid and efficient penetration to the skin. So it is beneficial for topical drug delivery. For topical delivery, microemulsion is incorporated in polymer gel base to prolong the local contact to the skin. Hydrophobic drugs can be incorporated into microemulsion based gel using drug/oil/water emulsions. Microemulsion based gel helps in the, incorporation of hydrophobic drugs into the oil phase and then oily globules are dispersed in an aqueous phase resulting in oil/water emulsion. Now days various polymers are used as gelling agent which make help to reduce the interfacial tension of oil and aqueous phase of microemulsion and also increasing the viscosity of the aqueous phase. In order to appreciate the potential of microemulsion gel as delivery carrier, this research gives a complete knowledge about properties, formulation consideration, phase behaviour, advantages and application of microemulsion based gel for drug delivery system.
Keywords: Nigella sativa seed oil, Thymoquinone, tween 20, tween 80, dehydrated xanthum gum, microemulsion based gel, topical drug delivery system, surfactant and co-surfactant.
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