Authors: Sourav Vashisht, Piyush Saxsena
Abstract: Artemether and lumefantrine are antimalarial medications used to treat malaria. The proposed study activity will create and analyse fast dissolving tablets (FDTs) of artemether and lumefantrine, which will avoid first-pass metabolism, improve dissolve rate, and increase bioavailability. Fast dissolving tablets (FDTs) were prepared via direct compression using a combination of superdisintegrants such as Crosspovidone and sodium starch glycolate (5%, 10%, and 15%) and evaluated for physicochemical evaluation parameters such as hardness, friability, weight variation, drug content uniformity, water absorption ratio, wetting time, in-vitro andisintegration time, and in-vitro dissolution studies. The control tablet (no superdisintegrant) was developed and tested. F1 through F6 formulations were developed, with F3 (crosspovidine) being the most optimised. The hardness, friability, weight fluctuation, and drug content were all determined to be within pharmacopoeia standards. The improved formulation, F3, had a water absorption ratio of 62.87%, a wetting time of 12 seconds, and an in-vitro disintegration time of 15 seconds. F3 was deemed the best formulation, releasing up to 99.49% (artemether) and 99.15% (lumefantrine) after 25 minutes. The best formulation, F3, was used to compare the dissolving rate profile of formulation and controlled formulation of artemether and lumefantrine tablets. The formulation, F3, demonstrated entire drug release in 25 minutes, while the controlled formulation demonstrated 26.50% (artemether) and 24.50% (lumefantrine) drug release in 25 minutes. The best formulation, F3, was also subjected to a stability analysis, which revealed that there was no significant change in any parameters. As a result, the formulation F3 was deemed extremely stable.
Keywords: Water Absorption Ratio, Fast Dissolving Tablets, Wetting Time, In-Vitro Dissolution Studies, Stability Studies
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