Author: Mehul Verma
Abstract: The study's goal was to create and optimise an oral medication delivery formulation of the hormonal contraceptive levonorgestrel. Pre-formulation tests were carried out to determine the medication excipient compatibilities. Crospovidone and sodium starch glycolate superdisintegrants were utilised to provide quick medication release from tablets. All pre-compression and post compression characteristics were examined for the manufactured tablets. FTIR was used to evaluate the drug-excipient interaction. The pharmacopoeial standard was met by all formulations. The study found that formulations created by direct compression F9 have the greatest dissolution employing both crospovidone and SSG, resulting in 93.13% quicker drug release over a 60-minute period, with a 45-second disintegration time when compared to other Levonorgestrel formulations. The current project's goal was accomplished by generating a product with the same release profile as the innovator's product. We may infer from this study that an instant release tablet of Levonorgestrel can be developed and has a better drug release response.
Keywords: Immediate Release, Levonorgestrel, Superdisintegrants, Direct Compression
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