Journal of Pharmaceutical Chemistry and Drug formulation ISSN: 3108-0782 (Online)

Authors: Priya Sharma, Dr. Anil Mehta

Abstract: The increasing prevalence of poorly soluble drugs has become a significant challenge in the pharmaceutical industry, as it directly impacts bioavailability and therapeutic efficacy. Novel drug delivery systems (NDDS) have emerged as a pivotal solution for enhancing the solubility, stability, and targeted delivery of such drugs. This paper explores the design and development of various NDDS, including solid dispersions, nanoparticles, liposomes, self emulsifying drug delivery systems (SEDDS), and polymeric micelles, highlighting their formulation strategies, characterization techniques, and clinical relevance. Additionally, critical parameters such as particle size, drug-polymer compatibility, and release kinetics are discussed to understand the optimization of these systems. The implementation of NDDS not only improves drug solubility but also reduces dosing frequency and minimizes adverse effects. Through systematic analysis and comparison, this study emphasizes the importance of integrating NDDS in modern pharmaceutics to overcome solubility-related challenges in drug therapy.

Keywords: Poorly soluble drugs, novel drug delivery systems, nanoparticles, solid dispersions, liposomes, bioavailability, polymeric micelles