Author: Dr. Priya Rathi, Dr. Ankit Mehra
Abstract: Targeted drug delivery systems (TDDS) represent a revolutionary approach in precision therapeutics, offering enhanced efficacy and reduced systemic toxicity. By directing active pharmaceutical ingredients specifically to diseased tissues or cells, TDDS improve therapeutic outcomes while minimizing adverse effects. This paper explores the design principles, development strategies, and current innovations in TDDS, including ligand-mediated targeting, nanocarriers, polymeric systems, and stimuli-responsive delivery. Emphasis is placed on formulation optimization, characterization techniques, and clinical applications. Comparative analyses highlight advantages over conventional drug delivery methods. Additionally, challenges such as stability, scalability, and regulatory considerations are discussed. The study concludes with future perspectives for integrating TDDS with emerging technologies like nanotechnology and personalized medicine to advance precision healthcare.
Keywords: Targeted drug delivery, Nanocarriers, Ligand-mediated targeting,Stimuli-responsive systems, Polymeric drug delivery, Precision therapeutics,Controlled release
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