Author: Sharmin Akhter, Md. Salahuddin, Md. Sajjad Hossen, Muazzem AhmedSunny, Marzia Rahman Tona, Md. Shahidul Islam
Abstract: Poor aqueous solubility and slow dissolution rate of the glimepiride lead to irreproducible clinical response or therapeutic failure in some cases due to sub therapeutic plasma drug levels. Glimepiride is a poorly water-soluble oral hypoglycemic drug exhibiting poor dissolution pattern. The purpose of this work is to increase the dissolution rate of glimepiride by formation of solid dispersion with different water soluble carriers. In this study, binary and ternary solid dispersion of glimepiride were prepared with poloxamer 407, polyethylene glycol 6000 (PEG 6000), polyethylene glycol 4000 (PEG 4000), and eudragit at different weight ratios using the solvent evaporation and melting method. Solvent evaporation method containing eudargit in ratio 1:2 ( Formulation coding: SE2) Showed the best result in comparison of other binary SD formulation by solvent evaporation technique which was released 6.19% after 5 min and 82.29% within 60 mins. Solvent evaporation technique of SD formulation of glimepiride contain poloxomer 407inratio1:9
(Formulationcoding:SE9) showed the best result the other formulation which was 44.71 % after 5 min and 72.68% within 60 mins. was also studied that the release kinetics of glimepiride of different SD formulation with different ratio such as, First order release kinetics, Higuchi, Krosmeyer, Hixoncrowell plot, and also be noted the MDT calculation for improving the solubility of glimepiride. Formulations were characterized by Fourier transform infrared (FTIR) and X-ray diffraction (XRD).No any chemical interaction was observed between polymer and drugs from IR spectrum. The drug was changed to amorphous form after solid dispersion.
Keywords: - Glimepiride, Dissolution Study, Formulation, IR spectrum
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