Formulation and Evaluation Of Sustained Release Tablets Using Natural Polymers

Abstract

Sustained release formulations play a vital role in maintaining consistent plasma drug concentrations over extended periods, thereby reducing dosing frequency and improving patient compliance. This study focuses on the formulation of sustained release tablets using natural polymers such as guar gum, xanthan gum, and chitosan. These biopolymers offer biodegradability, biocompatibility, and economic advantages compared to synthetic polymers. Wet granulation was employed to prepare the tablets, followed by evaluation of pre- and post-compression parameters, including hardness, friability, weight variation, and dissolution rate. In-vitro release studies demonstrated that polymer concentration significantly influenced drug release kinetics, conforming to Higuchi and Korsmeyer–Peppas models. Natural polymers proved effective in achieving controlled release profiles while ensuring the stability and integrity of the dosage form.

KEYWORDS: Sustained release, Natural polymers, Drug release kinetics, Biopolymers, Tablet formulation