Design and Synthesis of Novel Anti-Inflammatory Agents through Molecular Hybridization

Abstract

Inflammation underlies a wide range of chronic diseases, necessitating the discovery of more selective and effective anti-inflammatory agents. The current study investigates a novel approach in pharmaceutical chemistry through molecular hybridization, where pharmacophores of known anti-inflammatory drugs are combined to synthesize hybrid molecules. This method attempts to overcome resistance, minimize side effects, and improve pharmacokinetic properties. In the present work, a series of novel hybrids of indole and thiazolidinone scaffolds were synthesized and evaluated for their anti-inflammatory activities. Characterization was carried out using NMR, IR, and mass spectrometry. Biological screening was conducted using in-vitro COX inhibition assays. Several derivatives showed promising results with IC50 values lower than standard drugs, indicating high therapeutic potential. The results demonstrate the efficacy of molecular hybridization in rational drug design and open new avenues in drug formulation for inflammatory diseases.

Keywords: Molecular Hybridization, Anti-inflammatory Agents, Indole Derivatives, Drug Design, COX Inhibition.