Authors:-K. R Patel, Suraj Choudhary
Abstract:-Biopharmaceuticals, including monoclonal antibodies, recombinant proteins, and nucleic acid-based therapeutics, have gained prominence in modern medicine. The analysis of these complex molecules presents unique challenges due to their structural heterogeneity and intricate post-translational modifications. This paper discusses the key challenges encountered in the analysis of biopharmaceuticals and presents innovative solutions to address these issues.
Keywords:-Biopharmaceuticals, structural heterogeneity, high molecular weight, sensitivity to environmental factors, quantification, advanced mass spectrometry, high-resolution mass spectrometry, chromatographic techniques, size-exclusion chromatography.
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