Journal of Pharmaceutical Analysis and Drug Research ISSN: 3108-0839 (Online)

Authors: Bhautik Thummar, Dr. Jitendra Patel, Dr. Umesh Upadhyay

Abstract: Solubility is the property of a solid, liquid, or gaseous chemical substance called solute to dissolve in a solid, liquid, or gaseous solvent to form a homogeneous solution of the solute in the solvent. Solubility is one of the important parameters to achieve the desired concentration of drug in systemic circulation for achieving the required pharmacological response [12]. Poorly water-soluble drugs often require high doses in order to reach therapeutic plasma concentrations after oral administration. Low aqueous solubility is the major problem encountered with the formulation development of new chemical entities as well as generic development. This article is to focus on the Importance of Solubility, Techniques for Solubility Enhancement, Supercritical Fluid (SCF) Process, Cryogenic Techniques, Inclusion Complex Formation-Based Techniques, Hydrotrophy, Crystal Engineering, pH Adjustment, Co- Solvency etc.