Journal of Pharmaceutical Analysis and Drug Research ISSN: 3108-0839 (Online)

Authors: Dr. Y. Shravan Kumar, P. Samyuktha Rani, Ahamad Mohammad Saddam, Dr. B. Chandra Shekhar Reddy

Abstract: Oral fast dissolving drug delivery system (OFDDS) is one such novel approach to increase consumer acceptance by virtue of rapid disintegration, self-administration without water or chewing. Orally disintegrating tablets (ODT) are solid unit dosage forms like conventional tablets, but are composed of superdisintegrants, which help them to disintegrate the tablet rapidly in saliva without the need to take it water. Orally disintegrating tablets (ODT) are not only indicated for people who have swallowing difficulties, but also are ideal for active people. ODT were prepared by using Crospovidone, Sodium starch glycolate and Croscaramellose sodium by direct comparision method. Drug-polymer complex were formulated for drug content and then formulated into oral disintegrating tablets by direct compression method by using different concentrations of superdisintegrants. Tablets were evaluated for weight variation, hardness, thickness, friability, drug content, water absorption ratio, disintegration time, in-vivo and in-vitro drug release. Tablets of F9 formulation containing 6% Crosspovidone and sodium starch glycolate showed faster disintegration within 16.88 seconds. Good correlation was observed between in-vitro and in-vivo disintegration time. Correlation between water absorption and disintegration time showed that thewre exists an inverse relationship between them. In conclusion it was determined that Crosspovidone containing formulation showed better results when compared to others.