Authors: Dr. Radhika Sharma, Mr. Siddharth Rao
Abstract: Nanotechnology has revolutionized drug delivery by providing targeted, efficient, and controlled release of therapeutic agents. Analytical methods capable of characterizing nanoparticles, drug loading, release kinetics, and bio-distribution are crucial for the development and quality control of nanomedicine formulations. Techniques such as high-performance liquid chromatography (HPLC), liquid chromatography-mass spectrometry (LC MS), dynamic light scattering (DLS), atomic force microscopy (AFM), and nanoparticle tracking analysis (NTA) enable precise evaluation of nanocarrier systems. This paper reviews the principles, instrumentation, method development, sample preparation strategies, and applications of nanotechnology-based analytical methods in drug delivery systems. Emphasis is placed on the advantages of these methods in ensuring accurate characterization, regulatory compliance, and therapeutic efficacy. Integration of nanotechnology with advanced analytical tools accelerates the development of safe and effective drug delivery systems.
Keywords: Nanotechnology, Drug Delivery, Nanoparticles, Analytical Methods, HPLC, LC-MS, Dynamic Light Scattering, Nanomedicine
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