Journal of Pharmaceutical Analysis and Drug Research ISSN: 3108-0839 (Online)

Authors: Dr. Meera Kapoor, Mr. Rohit Nair

Abstract: Capillary electrophoresis (CE) has emerged as a versatile and high-efficiency analytical technique in pharmaceutical quality control. CE allows rapid separation of charged and neutral molecules based on their electrophoretic mobility, providing precise and reproducible analysis with minimal sample and solvent consumption. It has applications in drug purity assessment, impurity profiling, enantiomeric separation, and monitoring degradation products. This paper reviews principles, instrumentation, method development, sample preparation strategies, and applications of CE in pharmaceutical quality control. Emphasis is placed on the advantages of CE, including high resolution, rapid analysis, and environmental sustainability. Integration with detectors such as UV, fluorescence, and mass spectrometry further enhances sensitivity and selectivity. Implementing CE in quality control ensures compliance with regulatory standards and supports efficient, cost-effective pharmaceutical manufacturing.

Keywords: Capillary Electrophoresis, Pharmaceutical Quality Control, Impurity Profiling, Enantiomeric Separation, Drug Analysis, Analytical Methods, CE-MS