Authors: Dr. Priyanka Verma, Mr. Aditya Singh
Abstract: Recent advances in spectroscopic techniques have revolutionized pharmaceutical analysis, offering enhanced sensitivity, accuracy, and efficiency in drug characterization and quality control. Spectroscopic methods such as ultraviolet-visible (UV-Vis) spectroscopy, infrared (IR) spectroscopy, nuclear magnetic resonance (NMR), mass spectrometry (MS), and Raman spectroscopy are increasingly employed for qualitative and quantitative evaluation of pharmaceutical compounds. These techniques enable rapid detection of impurities, structural elucidation, and monitoring of stability and degradation products. This paper provides a comprehensive review of contemporary spectroscopic methodologies, discussing their principles, applications, advantages, and limitations. Emphasis is placed on hyphenated techniques and chemometric integration for improving analytical performance. The implementation of these innovative spectroscopic approaches ensures compliance with regulatory standards, accelerates drug development processes, and enhances pharmaceutical quality assurance.
Keywords: Spectroscopic Techniques, UV-Vis, NMR, Mass Spectrometry, Raman Spectroscopy, Pharmaceutical Analysis, Chemometrics
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