Authors: TanjinSharmily, Md. Shahidul Islam
Abstract: The research work comprises of interaction studies of Ceftriaxone with irbesartan and investigation of antimicrobial activity of Ceftriaxone. Ceftriaxone is included among the Cephalosporin drug class which is active against a wide range of gram positive and negative bacteria. This drug is used to treat many kinds of bacterial infections, including severe or life- threatening forms such as meningitis. Ceftriaxone is also used to prevent infection in people having certain types of surgery. Ceftriaxone interact with antihypertensive drug such as Irbesartan. Irbesartan is used to treat high blood pressure & to protect the kidneys from damage due to diabetes. lowering the blood pressure helps to prevent strokes ,heart attack & kidney problems, Irbesartan belongs to a class of drugs called angiotensin receptor blockers(ARBs). It works by relaxing blood vessels so that the blood can flow more easily.The reaction between Ceftriaxone &Irbesartan were simulated to natural environment. Also the antimicrobial activity of the drug and the complexes were determined. There is an effect of pH on drug-drug complexation. It has observed that Ceftriaxone interacts with Irbesartan on a pH 7.4, the stability constant of these complexes were determined in order to evaluate their possible in vivo implications. This research work confirms that there was a possible interaction between the Ceftriaxone &Irbesartanwhich was confirms by Jobs plot method and by antimicrobial investigation. By antimicrobial investigation it was observed that the zone of inhibition of the drug Ceftriaxone with Irbesartan reduced from 14mm to 10mm. In order to investigate the interaction of Irbesartan with Levofloxacin were elucidated by exploiting various spectrophotometric methods. The ultraviolet studies of these complexes were carried out and compared.
Keywords: -Ceftriaxone, Irbesartan, Complexation, Interaction, job’s Plot, Antimicrobial Study
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