ABSTRACT
Noncovalent interactions are crucial to biological processes. Noncovalent interactions help with anything from molecular recognition to molecular assembly to enzyme catalysis to the dynamic behaviour of biomolecules. Applications of noncovalent interactions in problems relating to many domains of chemistry, biology, and physics have become inevitably significant in recent years and are on the approach of becoming even more so. Noncovalent interactions that are dominated by electrostatic contributions have received the most attention and coverage due to their ubiquity and binding strength. Electrostatic interactions are directed and have a considerable range. However, due to the fundamental long range impactful character of electrostatic contributions, the directional elements of electrostatic dominated noncovalent interactions have been completely disregarded in the literature thus far. This thesis focuses on the importance and directional nature of long-range electrostatic interactions in order to completely understand the electrostatic contributions. We have given a brief overview of noncovalent bonds and their role in chemistry in this chapter. We also went over a brief history of the scientific literature to show how awareness of the importance of long-range electrostatic interactions has evolved over time.
KEYWORDS: Computing, Non-Covalent, Interactions, Applications, Biological Processes, Molecular Recognition.
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