International Journal of Toxicology and Pharmacological Sciences

Authors: Dr. Anirban Mukherjee, Dr. Neha Gupta

Abstract: Neurotoxicity, characterized by damage to the nervous system, can result from exposure to various environmental toxins and pharmaceutical agents. Inflammation plays a pivotal role in the pathophysiology of neurotoxicity, contributing to neuronal injury and neurodegenerative diseases. This paper reviews the inflammatory mechanisms underlying neurotoxicity, including the activation of microglia, release of pro-inflammatory cytokines, and the role of the blood-brain barrier in mediating neuroinflammatory responses. The interaction between inflammation and oxidative stress in exacerbating neuronal damage is discussed, alongside the potential for targeting inflammatory pathways as a therapeutic strategy. Emerging evidence on the use of anti-inflammatory drugs, natural compounds, and gene therapy to mitigate neuroinflammatory responses is also explored, providing insights into the development of effective treatments for neurotoxicity..

Keywords: Neurotoxicity, Inflammation, Microglia Activation, Blood-Brain Barrier, Therapeutic Targets