Author: Dr. Priya Mehta
Abstract: Cardiotoxicity, a severe adverse effect of many therapeutic agents, poses significant risks to patients undergoing pharmacological treatments. This paper examines the pharmacological interventions used to manage cardiotoxicity, focusing on the evaluation of drug safety and efficacy. Key mechanisms of cardiotoxicity, including oxidative stress, mitochondrial dysfunction, and calcium dysregulation, are discussed. The paper reviews current pharmacological strategies, such as the use of beta-blockers, ACE inhibitors, and antioxidants, to mitigate cardiotoxic effects. Additionally, emerging therapies, including novel drug delivery systems and genetic interventions, are explored for their potential to enhance cardiac protection and improve patient outcomes. The need for comprehensive preclinical and clinical assessments to evaluate the safety profiles of new pharmacological agents is also highlighted.
Keywords: Cardiotoxicity, Drug Safety, Pharmacological Interventions, Oxidative Stress, Efficacy Evaluation
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