International Journal of Toxicology and Pharmacological Sciences

Authors: Ravi Chawla, Neha Sood

Abstract: Drug-induced hepatotoxicity is a significant cause of liver injury and a major concern in pharmacology. Mitochondria, being crucial for cellular energy production and metabolic regulation, are primary targets for drug-induced toxicity. This review elucidates the mechanisms by which drugs disrupt mitochondrial function, leading to hepatocellular damage. Mechanisms such as the induction of oxidative stress, disruption of the mitochondrial membrane potential, inhibition of the electron transport chain, and depletion of adenosine triphosphate (ATP) are explored in detail. The review also discusses potential therapeutic interventions, including antioxidants, mitochondrial-targeted agents, and lifestyle modifications, to mitigate mitochondrial dysfunction and prevent hepatotoxicity. Recent advancements in the understanding of mitochondrial dynamics and the role of mitophagy in maintaining mitochondrial health are also highlighted, providing a comprehensive overview of the current state of knowledge in this field.

Keywords: Mitochondrial Dysfunction, Drug-Induced Hepatotoxicity, Oxidative Stress, Therapeutic Interventions, Hepatocellular Damage