International Journal of Toxicology and Pharmacological Sciences

Authors:Sai Ramya Polukonda, Nishitha Mohan, Vidhu Maheshwari

Abstract:Neurodegenerative diseases pose significant challenges to public health and present a growing burden on healthcare systems worldwide. These disorders, including Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis, are characterized by progressive degeneration and dysfunction of the nervous system. Despite extensive research efforts, effective disease-modifying treatments for neurodegenerative diseases remain elusive. This paper aims to explore the potential of novel pharmacological targets that hold promise in the treatment of neurodegenerative diseases, focusing on emerging therapeutic strategies and their underlying mechanisms of action. By understanding the intricacies of these novel targets, researchers and clinicians can develop innovative therapies to address the urgent need for disease-modifying treatments.

Keywords:Neurodegenerative diseases, protein misfolding, epigenetic modifications, neuroinflammation, excitotoxicity, mitochondrial dysfunction, personalized medicine, drug repurposing, combination therapies.