Metabolomics-Guided Standardization of Polyherbal Formulations

Abstract

Polyherbal formulations, a cornerstone of traditional medicine, are gaining global recognition due to their synergistic therapeutic potential. However, standardization of these complex mixtures remains a challenge due to variability in raw materials, preparation methods, and phytochemical compositions. Metabolomics, a systems-level analytical approach, provides comprehensive profiling of metabolites, enabling precise characterization and quality control of polyherbal formulations. This review highlights the role of metabolomics in standardizing polyherbal products, discusses analytical techniques, identifies challenges, and explores future directions for integrating metabolomics in herbal drug development. The integration of metabolomics into polyherbal standardization promises enhanced reproducibility, efficacy, and safety, ultimately bridging traditional knowledge with modern scientific rigor.

KEYWORDS: Polyherbal formulations, Metabolomics, Standardization, Herbal medicine, Quality control, LC-MS, NMR