Author: Abhishek Verma
Abstract: The bioavailability of drugs significantly influences their therapeutic efficacy. Poorly soluble drugs often present challenges in achieving adequate plasma concentrations to produce the desired therapeutic effects. This paper discusses various formulation strategies designed to enhance the bioavailability of poorly soluble drugs. These strategies include solid dispersions, lipid-based formulations, nanosuspensions, and cyclodextrin complexes, among others. The paper also highlights the physicochemical properties influencing drug solubility and bioavailability, providing an in-depth analysis of each strategy’s mechanism of action, advantages, and limitations. Additionally, the paper explores current trends in drug formulation and the potential future directions to overcome solubility challenges, ultimately improving drug delivery systems for better clinical outcomes.
Keywords: Bioavailability, Poorly Soluble Drugs, Drug Formulation, Solid Dispersions, Nanosuspensions, Lipid-Based Formulations, Cyclodextrins, Drug Delivery
Full Issue
| View or download the full issue | PDF 97-103 |