International Journal of Pharmacognosy and Phytochemical Sciences

Authors: Shweta Mehta, Kailash Saini, Deepak Jain

Abstract: Neurodegenerative diseases, such as Alzheimer's, Parkinson's, and Huntington's, present complex challenges in healthcare, as they involve progressive deterioration of neural function. Increasing research into phytochemicals—bioactive compounds from plants—indicates their therapeutic potential in managing and possibly slowing the progression of these diseases. This paper explores the mechanisms by which phytochemicals exert neuroprotective effects, their role in reducing oxidative stress, inflammation, and apoptosis, and their influence on cellular signaling pathways. The review also evaluates the bioavailability and clinical efficacy of phytochemical-based treatments, providing insights into future directions for phytochemical use in neurodegenerative disease management.

Keywords: Phytochemicals, Neurodegenerative Diseases, Alzheimer's, Parkinson's, Antioxidants, Neuroprotection, Inflammation, Apoptosis